Key result
Moexipril 15 mg once daily for 24 weeks significantly decreased left ventricular mass index from 121 to 103 g/m (P < 0.001) in patients with essential hypertension and left ventricular hypertrophy.
Why the study?
Does moexipril 15 mg once daily reduce left ventricular mass index in patients with mild to moderate essential hypertension and left ventricular hypertrophy?
Population
72 patients with mild to moderate essential hypertension and left ventricular hypertrophy, mean age 49, 69%…
Design
Cohort, nonrandomized, single-blind
Follow-up
24 weeks
Authors
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Supports LV mass regression with moexipril in hypertensive LVH; observational data leaves open randomized confirmation before practice change.
Does moexipril 15 mg once daily reduce left ventricular mass index in patients with mild to moderate essential hypertension and left ventricular hypertrophy?
Absolute Event Rate: 103% vs 121%
p-value: p=< 0.001
Moexipril 15 mg daily significantly reduces left ventricular mass index and blood pressure in patients with essential hypertension and LVH over 24 weeks.
Sayegh et al. (2005) studied essential hypertension with left ventricular hypertrophy (n=72). moexipril vs. baseline was evaluated on decrease of left ventricular mass index (LVMIs) (p=< 0.001). Moexipril 15 mg once daily for 24 weeks significantly decreased left ventricular mass index from 121 to 103 g/m (P < 0.001) in patients with essential hypertension and left ventricular hypertrophy.
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