Why the study?
Does lisinopril reduce ambulatory blood pressure and left ventricular hypertrophy compared to hydralazine in hypertensive men with left ventricular hypertrophy?
Population
30 male patients with essential hypertension despite combined beta-blocker/diuretic therapy, with…
Comparison
Lisinopril for 6 months vs Hydralazine slow release 50 mg / chlorthalidone…
Design
RCT, randomized
Follow-up
6 months
Authors
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Lisinopril may be preferred over hydralazine for LVH regression and nocturnal BP control in hypertension; extends randomized evidence on differential target-organ effects.
Does lisinopril reduce ambulatory blood pressure and left ventricular hypertrophy compared to hydralazine in hypertensive men with left ventricular hypertrophy?
Lisinopril is superior to hydralazine in regressing left ventricular hypertrophy and lowering night-time blood pressure in patients with resistant hypertension.
Fogari et al. (1995) studied this question.
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