Key result
Lisinopril reduces left ventricular mass index by ~14 g/m² more than diltiazem at 6 months.
Why the study?
The comparative effects of diltiazem and lisinopril on left ventricular mass and diastolic filling in untreated mild-to-moderate hypertension were not well established.
Does diltiazem compared to lisinopril improve left ventricular mass and diastolic filling in previously untreated patients with mild-to-moderate hypertension?
Comparison
Diltiazem 300 mg once daily vs lisinopril 20 mg once daily
Design
Comparative cohort study
Follow-up
6 months
Authors
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Lisinopril may be preferred over diltiazem for LV mass regression in hypertension; confirms ACEI advantage in cardiac remodeling.
Does diltiazem compared to lisinopril improve left ventricular mass and diastolic filling in previously untreated patients with mild-to-moderate hypertension?
Mean Difference: 13.7 (95% CI 0.8–26.6)
p-value: p=< 0.05
Lisinopril is more effective than diltiazem at reducing left ventricular mass and ambulatory blood pressure in patients with mild-to-moderate hypertension.
Leeuwen et al. (1995) studied Mild-to-moderate hypertension (n=36). Lisinopril vs. Diltiazem 300 mg once daily was evaluated on Left ventricular (LV) mass index (MD 13.7, 95% CI 0.8 to 26.6, p=< 0.05). Lisinopril resulted in a significantly greater reduction in left ventricular mass index compared to diltiazem after 6 months of treatment (mean difference 13.7 g/m2; 95% CI 0.8-26.6; p<0.05).
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