Why the study?
Does amlodipine compared to lisinopril improve left ventricular mass index and diastolic filling in patients with untreated mild to moderate diastolic hypertension?
Population
71 patients aged 25 to 75 years with previously untreated mild to moderate diastolic hypertension recruited…
Comparison
Amlodipine 5-10 mg titrated based on blood… vs Lisinopril 10-20 mg titrated based on blood…
Design
RCT, randomized, parallel group, double-blind
Follow-up
1 year
Authors
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Both agents reduce LVMI similarly; confirms comparable effects on LV remodeling in mild diastolic hypertension.
Does amlodipine compared to lisinopril improve left ventricular mass index and diastolic filling in patients with untreated mild to moderate diastolic hypertension?
Amlodipine and lisinopril are similarly effective in reducing left ventricular mass index after 1 year of treatment in patients with mild to moderate diastolic hypertension.
Frank W. Beltman (1998) studied this question.
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