Why the study?
Does amlodipine compared to lisinopril reduce intima-media thickness in previously untreated, elderly hypertensive patients?
Population
166 newly diagnosed hypertensive individuals with diastolic blood pressure between 95 and 115 mmHg or…
Comparison
Amlodipine 5-10 mg for 2 years vs Lisinopril 10-20 mg for 2 years
Design
RCT, randomized parallel-group, double-blind
Follow-up
2 years
Authors
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Either agent supports IMT regression in elderly hypertension; confirms class equivalence for vascular remodeling.
Does amlodipine compared to lisinopril reduce intima-media thickness in previously untreated, elderly hypertensive patients?
Amlodipine and lisinopril provide similar reductions in carotid and femoral intima-media thickness over 2 years in newly diagnosed elderly hypertensive patients.
Terpstra et al. (2004) studied this question.
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