Why the study?
Does enalapril compared to lisinopril improve blood pressure control in patients with mild-moderate hypertension?
Population
58 patients with mild-moderate hypertension (49 males and 9 females, mean age 50.9)
Comparison
Enalapril 20 mg oral once daily for 4 weeks vs Lisinopril 20 mg oral once daily for 4 weeks
Design
RCT, randomized parallel group, double-blind
Follow-up
4 weeks
Authors
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Equivalence supports interchangeable use of enalapril or lisinopril for hypertension; confirms similar BP efficacy despite differential ACE inhibition.
Does enalapril compared to lisinopril improve blood pressure control in patients with mild-moderate hypertension?
Enalapril and lisinopril provide equivalent blood pressure lowering efficacy in mild-moderate hypertension despite differences in the degree of serum ACE activity suppression.
Enström et al. (1992) studied this question.
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