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June 1, 1992Journal of Cardiovascular Pharmacology

Antihypertensive Effect of Lisinopril Assessed by 24-Hour Ambulatory Monitoring: A Double-Blind, Placebo-Controlled, Cross-Over Study

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Why the study?

Does lisinopril 20 mg reduce 24-hour ambulatory blood pressure in patients with mild to moderate hypertension compared to placebo?

Population

24 patients with mild to moderate hypertension, mean age 52 +/- 6 years, 21 men and 3 women.

Comparison

Lisinopril 20 mg administered for 4 weeks. vs Placebo administered for 4 weeks.

Design

RCT, Randomly assigned to two consecutive treatments, Double-blind…

Follow-up

4 weeks per treatment period

Authors

RTR. TotneiUniversity of VeronaLRLaura RossiLeeds Teaching Hospitals NHS TrustECEmanuele CarbonieriUniversity of Verona

Discussion

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Implication

Supports lisinopril 20 mg in mild-moderate hypertension; confirms ambulatory BP efficacy in RCTs.

Structured PICO

Does lisinopril 20 mg reduce 24-hour ambulatory blood pressure in patients with mild to moderate hypertension compared to placebo?

P
Population
24 patients with mild to moderate hypertension, mean age 52 +/- 6 years, 21 men and 3 women.
I
Intervention
Lisinopril 20 mg administered for 4 weeks.
C
Comparator
Placebo administered for 4 weeks.
O
Outcome
Blood pressure assessed by noninvasive 24-hour ambulatory blood pressure monitoring (ABPM) on the last day of treatment.surrogate

Lisinopril 20 mg significantly reduces 24-hour ambulatory systolic and diastolic blood pressure in patients with mild to moderate hypertension.

Cite This Study

Totnei et al. (1992) studied this question.

synapsesocial.com/papers/6a71e1806ceb2bbd16e0400ahttps://doi.org/10.1097/00005344-199206000-00011
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antihypertensive Efficacy of Lisinopril Ambulatory Blood Pressure Monitoring1988 · 24 citations
  2. 2Assessment of Antihypertensive Effect by Blood Pressure Monitoring: Applications to Bisoprolol and Lisinopril in a Double-Blind Study1997 · 5 citations
  3. 3Efficacy of once‐daily lisinopril monotherapy in systemic hypertension1993 · 2 citations
  4. 4Differences in the Acute and Chronic Antihypertensive Effects of Lisinopril and Enalapril Assessed by Ambulatory Blood Pressure Monitoring1993 · 17 citations
  5. 5Different hemodynamic (24‐h ambulatory blood pressure monitoring) and renin‐inhibiting effect of a 1‐week treatment with enalapril and lisinopril1991