Why the study?
Does a single dose of lisinopril 20 mg compared to enalapril 10 mg reduce plasma Angiotensin II levels in normal subjects?
Population
8 normal subjects
Comparison
Lisinopril 20 mg single oral administration vs Enalapril 10 mg single oral administration
Design
Other
Follow-up
24 hours
Authors
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Similar Ang II suppression by single-dose lisinopril and enalapril in healthy subjects; leaves open whether sustained ACE inhibition affects outcomes in patients.
Does a single dose of lisinopril 20 mg compared to enalapril 10 mg reduce plasma Angiotensin II levels in normal subjects?
A single 20 mg dose of lisinopril and 10 mg of enalapril show similar potency for lowering circulating Angiotensin II levels in healthy subjects, despite lisinopril having a more sustained effect on serum ACE activity.
Kawamura et al. (1990) studied this question.
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