Key result
Lisinopril and nifedipine both effectively reversed left ventricular hypertrophy to the same level, although lisinopril decreased left ventricular mass index more rapidly.
Why the study?
Does lisinopril compared to nifedipine improve left ventricular hypertrophy in patients with essential hypertension?
Population
38 patients with essential hypertension and left ventricular hypertrophy
Comparison
Lisinopril for 24 weeks vs Nifedipine for 24 weeks
Design
Single-blind
Follow-up
48 weeks (24 weeks per treatment arm)
Authors
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Either agent supports LVH regression in hypertension; leaves open whether faster reduction with lisinopril improves outcomes.
RCT (n=38)
Single-blind
Does lisinopril compared to nifedipine improve left ventricular hypertrophy in patients with essential hypertension?
Both lisinopril and nifedipine effectively reverse hypertensive left ventricular hypertrophy, but lisinopril achieves this more rapidly through improved aortic compliance rather than just blood pressure reduction.
Shimamoto et al. (1996) conducted an RCT in Essential hypertension with left ventricular hypertrophy (n=38). Lisinopril vs. Nifedipine was evaluated on Left ventricular mass index and mean arterial pressure. Lisinopril and nifedipine both effectively reversed left ventricular hypertrophy to the same level, although lisinopril decreased left ventricular mass index more rapidly.
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