Key result
Lisinopril significantly reduced blood pressure and increased renal blood flow without changing heart rate, cardiac output, or glomerular filtration rate.
Why the study?
Does lisinopril improve renal and cardiac hemodynamics compared to nifedipine in patients with moderate to severe primary hypertension?
Population
15 patients with moderate to severe primary hypertension
Comparison
Lisinopril 20-80 mg once daily vs Nifedipine 20-40 mg twice daily
Design
RCT, randomized in a 2:1 ratio, double-blind
Authors
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Supports lisinopril for hypertension with renal flow gains; extends RCT evidence for ACEI hemodynamic effects without altering CO or GFR.
RCT (n=15)
Double-blind
2:1 ratio
Yes
Does lisinopril improve renal and cardiac hemodynamics compared to nifedipine in patients with moderate to severe primary hypertension?
Lisinopril is an effective antihypertensive agent that favorably increases renal blood flow without altering glomerular filtration rate or cardiac output in patients with moderate to severe hypertension.
Dupont et al. (1987) conducted an RCT in Moderate to severe primary hypertension (n=15). Lisinopril vs. Nifedipine was evaluated on Blood pressure and renal/cardiac hemodynamics. Lisinopril significantly reduced blood pressure and increased renal blood flow without changing heart rate, cardiac output, or glomerular filtration rate.
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