Why the study?
Does lisinopril reduce blood pressure more effectively or with better tolerability than nifedipine in patients with mild to moderate hypertension?
Does lisinopril reduce blood pressure more effectively or with better tolerability than nifedipine in patients with mild to moderate hypertension?
Lisinopril 10-40 mg once daily is as effective as nifedipine 20-40 mg twice daily for lowering diastolic blood pressure and may be better tolerated in patients with mild to moderate hypertension.
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Supports lisinopril preference over nifedipine for systolic control in mild-moderate hypertension; extends RCT comparisons of ACEI versus CCB.
Hart et al. (1993) studied this question.
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