Key result
Lisinopril and nifedipine similarly lowered blood pressure, but lisinopril produced a greater increase in baroreflex sensitivity in response to reduced carotid transmural pressure (P<0.05).
Why the study?
Does lisinopril improve baroreflex sensitivity compared to nifedipine in older patients with mild-to-moderate hypertension?
RCT (n=13)
Double-blind
Crossover
Does lisinopril improve baroreflex sensitivity compared to nifedipine in older patients with mild-to-moderate hypertension?
p-value: p=<0.05
Lisinopril improves baroreflex sensitivity more than nifedipine in older hypertensive patients, independent of blood pressure reduction.
Authors
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Lisinopril improves baroreflex sensitivity beyond BP reduction in older hypertensives; extends evidence for ACEI-specific autonomic effects in RCTs.
Egan et al. (1993) conducted an RCT in Mild-to-moderate hypertension (n=13). Lisinopril vs. Nifedipine GITS 30-90 mg/day and placebo was evaluated on Ambulatory blood pressure values, laboratory hemodynamics, and baroreflex sensitivity (p=<0.05). Lisinopril and nifedipine similarly lowered blood pressure, but lisinopril produced a greater increase in baroreflex sensitivity in response to reduced carotid transmural pressure (P<0.05).
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