August 1, 1990British Journal of Clinical PharmacologyOpen Access

Enalapril and nifedipine in the treatment of mild to moderate essential hypertension: a 6 month comparison.

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Why the study?

Does enalapril compared to nifedipine improve blood pressure control in patients with mild to moderate essential hypertension?

Population

128 patients with mild to moderate essential hypertension

Comparison

Enalapril 10-40 mg once daily for 6 months vs Nifedipine retard 10-40 mg twice daily for 6…

Design

RCT, randomised, parallel group, double-blind, double dummy technique

Follow-up

6 months

Authors

DMDerek MacleanSouthampton General Hospital LRLE RamsayHouston Methodist PRPJ RichardsonKing's College London

Discussion

Member takes

Implication

Enalapril and nifedipine yield comparable BP control in mild-moderate hypertension; confirms similar efficacy for initial monotherapy selection.

Structured PICO

Does enalapril compared to nifedipine improve blood pressure control in patients with mild to moderate essential hypertension?

Population

128 patients with mild to moderate essential hypertension (sitting diastolic blood pressure between 95 and 125 mm Hg after 2-4 weeks run-in on placebo)

Intervention

Enalapril 10-40 mg once daily (with hydrochlorothiazide 12.5-50 mg once daily added for inadequate responders) for 6 months

Comparator

Nifedipine retard 10-40 mg twice daily (with hydrochlorothiazide 12.5-50 mg once daily added for inadequate responders) for 6 months, using double dummy technique

Outcome

Achievement of dual target blood pressures (<150 mm Hg systolic and <90 mm Hg sitting diastolic) and blood pressure reduction at 6 monthssurrogate

Enalapril and nifedipine provide comparable blood pressure reductions in mild to moderate essential hypertension, with differing adverse event profiles.

Cite This Study

Maclean et al. (1990) studied this question.

synapsesocial.com/papers/6a72724cfe4101aa97e0da51 https://doi.org/10.1111/j.1365-2125.1990.tb03766.x

Topics

Hypertension management

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Implication

Enalapril and nifedipine yield comparable BP control in mild-moderate hypertension; confirms similar efficacy for initial monotherapy selection.

Enalapril and nifedipine in the treatment of mild to moderate essential hypertension: a 6 month comparison.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Enalapril and nifedipine in the treatment of mild to moderate essential hypertension: a 6 month comparison.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider