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October 1, 1990Journal of Cardiovascular Pharmacology

Pharmacokinetics and Antihypertensive Effects of Lisinopril in Hypertensive Patients with Normal and Impaired Renal Function

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Why the study?

How do the pharmacokinetics and antihypertensive effects of lisinopril differ between hypertensive patients with normal versus impaired renal function?

Population

17 hypertensive patients, comprising 9 with normal renal function and 8 with impaired renal function.

Design

Cohort

Follow-up

5 or 8 days

Authors

HSHiroshi ShionoiriYokohama City UniversityKMKohsuke MinamisawaKanagawa Prefecture Medical AssociationSUShinichiro UedaGeneral / Preventive / Lipids

Discussion

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Implication

May warrant dose caution in renal impairment; extends PK data but leaves open outcome effects.

Structured PICO

How do the pharmacokinetics and antihypertensive effects of lisinopril differ between hypertensive patients with normal versus impaired renal function?

P
Population
17 hypertensive patients, comprising 9 with normal renal function (mean serum creatinine 1.0 mg/dl) and 8 with impaired renal function (mean serum creatinine 1.7 mg/dl).
I
Intervention
Lisinopril 10 mg orally once daily for 5 or 8 days.
O
Outcome
Antihypertensive effects (blood pressure) and pharmacokinetic properties (plasma levels, peak levels, AUC) measured on the first and last days of treatment.surrogate

Lisinopril provides sustained antihypertensive effects, but its clearance is reduced in patients with impaired renal function, necessitating careful dose consideration.

Cite This Study

Shionoiri et al. (1990) studied this question.

synapsesocial.com/papers/6a8c3cd39d5fb440a3becf9dhttps://doi.org/10.1097/00005344-199010000-00010

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ANTIHYPERTENSIVE AND HORMONAL EFFECTS OF LISINOPRIL, A NEW ANGIOTENSIN CONVERTING ENZYME (ACE) INHIBITOR IN PATIENTS WITH RENOVASCULAR HYPERTENSION.1986 · 8 citations
  2. 2Hemodynamic, Hormonal, and Pharmacokinetic Aspects of Treatment with Lisinopril in Congestive Heart Failure1987 · 22 citations
  3. 3Improved Renal Function During Chronic Lisinopril Treatment in Moderate to Severe Primary Hypertension1987 · 13 citations
  4. 4Lisinopril in Hypertension Associated with Renal Impairment1987 · 13 citations
  5. 5Antihypertensive Effect of Lisinopril Assessed by 24-Hour Ambulatory Monitoring: A Double-Blind, Placebo-Controlled, Cross-Over Study1992 · 8 citations