Key result
Less correlated pre-ablation PV electrical activity with higher delays is linked to AF recurrence.
Why the study?
Up to half of patients undergoing pulmonary vein ablation for AF experience recurrences during the first year.
Does the spatial organization of pulmonary vein electrical activity prior to ablation predict atrial fibrillation recurrence?
Observational
Does the spatial organization of pulmonary vein electrical activity prior to ablation predict atrial fibrillation recurrence?
Higher spatial organization and correlation of electrical activations at the pulmonary veins prior to ablation is associated with maintenance of sinus rhythm in patients with atrial fibrillation.
Answers are grounded in this paper and cite their sources.
Pre-ablation PV disorganization was associated with AF recurrence; hypothesis-generating for predictive mapping before ablation.
Ablation of pulmonary veins has emerged as a key procedure for normal rhythm restoration in atrial fibrillation patients. However, up to half of ablated Atrial fibrillation (AF) patients suffer recurrences during the first year. In this article, simultaneous intra-atrial recordings registered at pulmonary veins previous to the ablation procedure were analyzed. Spatial cross-correlation and transfer entropy were computed in order to estimate spatial organization. Results showed that, in patients with arrhythmia recurrence, pulmonary vein electrical activity was less correlated than in patients that maintained sinus rhythm. Moreover, correlation function between dipoles showed higher delays in patients with AF recurrence. Results with transfer entropy were consistent with spatial cross-correlation measurements. These results show that arrhythmia drivers located at the pulmonary veins are associated with a higher organization of the electrical activations after the ablation of these sites.
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Cervigón et al. (2020) conducted an observational in Atrial fibrillation. Pre-ablation intra-atrial recordings analysis vs. Patients maintaining sinus rhythm was evaluated on Spatial organization of pulmonary vein electrical activity (spatial cross-correlation and transfer entropy). Pre-ablation pulmonary vein electrical activity was less correlated and showed higher delays between dipoles in patients with atrial fibrillation recurrence compared to those maintaining sinus rhythm.
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