Key result
Patients with atrial fibrillation recurrence after ablation showed higher spatial organization dispersion along pulmonary veins compared to those maintaining sinus rhythm (0.14 vs 0.07, p<0.001).
Why the study?
Intracardiac electrograms obtained prior to ablation were analyzed to evaluate whether quantifying temporal, frequency, and spatial organization could predict AF recurrence after the intervention.
Does time and frequency domain analysis of pulmonary vein electrograms before ablation predict atrial fibrillation recurrence in patients undergoing AF ablation?
Observational (n=10)
Does time and frequency domain analysis of pulmonary vein electrograms before ablation predict atrial fibrillation recurrence in patients undergoing AF ablation?
Absolute Event Rate: 0.14% vs 0.07%
p-value: p=<0.001
Higher dispersion in spatial organization of pulmonary vein electrograms prior to isolation may serve as a predictor for atrial fibrillation recurrence after ablation.
May aid risk stratification for post-ablation AF recurrence; leaves open need for prospective validation before clinical use.
Time and frequency domain analysis has been applied to atrial electrograms to quantify the temporal and spatial organization during atrial fibrillation (AF). Intracardiac recordings obtained before AF ablation procedure were analyzed in order to predict the recurrence outcome of AF after an ablation intervention. Such analysis may be used to quantify both temporal/ frequency and spatial organization during AF. Pulmonary vein electrogram recordings from ten AF patients were analyzed. Results showed changes in spectral characteristics with higher dispersion in spatial organization along the pulmonary veins in patients that had recurrence in the arrhythmia 0.140.01 vs. 0.070.02 in patients that maintained sinus rhythm (p<0.001). Moreover, similar results were obtained by frequency and temporal domain analysis. The proposed analysis could be useful for a better understanding of electrophysiological mechanisms during AF in both groups of patients, where the electrical activity is collected from electrodes located in the pulmonary veins area before the isolation procedure.
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Cervigón et al. (2018) conducted an observational in Atrial Fibrillation (n=10). Pulmonary vein electrogram analysis vs. Patients maintaining sinus rhythm was evaluated on Spectral coherence standard deviation (dispersion in spatial organization) (p=<0.001). Patients with atrial fibrillation recurrence after ablation showed higher spatial organization dispersion along pulmonary veins compared to those maintaining sinus rhythm (0.14 vs 0.07, p<0.001).
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