Key result
Lisinopril 20 mg administration showed that 4-6 hours post-dose serum ACE activity (< 5 EU/L) and elevated angiotensin I (> 300 pg/ml) can confirm compliance with ACE-inhibitor treatment.
Why the study?
Can serum ACE activity and angiotensin levels be used to assess compliance with lisinopril therapy in normotensive male volunteers?
RCT (n=16)
Double-blind
randomized
Can serum ACE activity and angiotensin levels be used to assess compliance with lisinopril therapy in normotensive male volunteers?
Serum ACE activity < 5 EU/L and elevated Angiotensin I > 300 pg/ml measured 4-6 hours post-dose may serve as useful biomarkers to confirm compliance with ACE inhibitor therapy.
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May aid clinicians in verifying ACE-inhibitor adherence; extends biomarker validation to lisinopril in RCTs.
MacFadyen et al. (1997) conducted an RCT in Normotensive male volunteers (n=16). Lisinopril vs. Placebo was evaluated on Serum ACE activity and angiotensin levels. Lisinopril 20 mg administration showed that 4-6 hours post-dose serum ACE activity (< 5 EU/L) and elevated angiotensin I (> 300 pg/ml) can confirm compliance with ACE-inhibitor treatment.
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