Key result
Elevated serum ACE activity predicts ACE inhibitor non-adherence in heart failure patients with ~91% accuracy.
Why the study?
Does routine serum ACE activity measurement accurately reflect patient adherence to ACE inhibitor treatment in patients with chronic heart failure?
Observational (n=73)
No
Does routine serum ACE activity measurement accurately reflect patient adherence to ACE inhibitor treatment in patients with chronic heart failure?
Routine serum ACE activity assays can serve as a simple, inexpensive tool to identify non-adherence to ACE inhibitor therapy in patients with chronic heart failure.
No takes yet. Share an insight, caveat, or question.
May support ACE activity as HF adherence marker but should not yet change practice; leaves open prospective validation.
Struthers et al. (1999) conducted an observational in chronic heart failure (CHF) (n=73). Serum ACE activity was evaluated on Correlation of routine collected serum ACE measurements with measured adherence with ACE inhibitor treatment. Routine serum ACE activity >12 U/L predicted <100% adherence to ACE inhibitors with 91% accuracy, whereas levels <6.5 U/L predicted >85% adherence with 81% accuracy in heart failure patients.
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