Current use of selective serotonin reuptake inhibitors was associated with an increased risk of uncomplicated peptic ulcers (OR 1.50; 95% CI 1.18-1.90).
Case-Control (n=24,310)
No
Does the use of SSRIs increase the risk of uncomplicated peptic ulcers?
Current use of SSRIs is associated with a 50% increased odds of uncomplicated peptic ulcers, suggesting a potential ulcerogenic effect or interference with ulcer healing.
Effect estimate: OR 1.50 (95% CI 1.18-1.90)
BACKGROUND: Persons who use serotonin reuptake inhibitors (SSRIs) seem to be at increased risk of having serious upper gastrointestinal bleeding. In vitro studies have shown that SSRIs inhibit platelet aggregation. It remains unknown if SSRIs have a direct ulcerogenic effect. AIM: To investigate if there is a possible association between use of SSRIs and uncomplicated peptic ulcers. METHODS: A population-based case-control study was conducted in the county of Funen, Denmark, using local prescription database and patient register. The 4862 cases all had a first diagnosis of uncomplicated peptic ulcers from 1995 to 2009. Controls (n = 19 448), matched for age and gender, were selected by risk-set sampling. RESULTS: The adjusted odds ratios (OR) of uncomplicated peptic ulcers among current, recent and past users of SSRIs were 1.50 (95% CI 1.18-1.90), 1.56 (95% CI 0.98-2.49) and 1.32 (95% CI 1.08-1.61). There was no association with tricyclic antidepressants OR 0.94 (95% CI 0.65-1.35). The adjusted OR for the SSRI-uncomplicated peptic ulcers association was 0.76 (95% CI 0.46-1.25) among users of proton pump inhibitors. CONCLUSIONS: Use of SSRI is associated with uncomplicated peptic ulcers, possibly by some effect on the healing process. We cannot exclude some effects of residual confounding or bias by frequent physician contact.
Dall et al. (Wed,) conducted a case-control in Uncomplicated peptic ulcers (n=24,310). Selective serotonin reuptake inhibitors (SSRIs) vs. Non-use of SSRIs was evaluated on Uncomplicated peptic ulcers (OR 1.50, 95% CI 1.18-1.90). Current use of selective serotonin reuptake inhibitors was associated with an increased risk of uncomplicated peptic ulcers (OR 1.50; 95% CI 1.18-1.90).