Key result
Helicobacter pylori infection significantly increased the risk of serious upper gastrointestinal bleeding among users of selective serotonin reuptake inhibitors (OR 2.73; 95% CI 1.17-6.36).
Why the study?
Does H. pylori infection increase the risk of serious upper gastrointestinal bleeding in users of selective serotonin reuptake inhibitors?
Case-Control (n=776)
Does H. pylori infection increase the risk of serious upper gastrointestinal bleeding in users of selective serotonin reuptake inhibitors?
H. pylori infection significantly potentiates the risk of serious upper gastrointestinal bleeding among patients taking SSRIs.
May warrant H. pylori testing in SSRI users at GI risk; leaves open whether eradication reduces bleeding events.
BACKGROUND: A number of studies have reported a possible association between use of selective serotonin reuptake inhibitors (SSRIs) and serious upper gastrointestinal bleeding (UGB). We conducted this case-control study to assess if Helicobacter pylori (H. pylori) potentiates the risk of serious UGB in SSRI users. MATERIAL AND METHODS: A population-based case-control study was conducted in the county of Funen, Denmark. Cases were 53 SSRI users with serious UGB whose H. pylori status on their bleeding date could be established. Controls (n = 723) were selected among subjects who participated in a population H. pylori screening study, and who were users of SSRIs. Data on drug exposure and medical history were retrieved from a prescription database and the county's patient register. Confounders were controlled for by unconditional logistic regression. RESULTS: H. pylori infection increased the risk of serious UGB in patients using SSRI with an adjusted odds ratio (OR) of 2.73 (95% confidence interval (CI), 1.17-6.36). The adjusted OR for serious UGB among users of non-steroidal anti-inflammatory drugs (NSAIDs) and acetylsalicylic acid (ASA) were 3.91 (95% CI, 2.03-7.52) and 3.00 (95% CI, 0.94-9.54), respectively. CONCLUSION: H. pylori infection increases the risk of SSRI-related serious UGB.
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Dall et al. (2011) conducted a case-control in Selective serotonin reuptake inhibitor (SSRI) users (n=776). Helicobacter pylori infection vs. No Helicobacter pylori infection was evaluated on Serious upper gastrointestinal bleeding (OR 2.73, 95% CI 1.17-6.36). Helicobacter pylori infection significantly increased the risk of serious upper gastrointestinal bleeding among users of selective serotonin reuptake inhibitors (OR 2.73; 95% CI 1.17-6.36).
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