Key result
Discordant alternans arises dynamically from action potential duration and conduction velocity restitution properties, markedly increasing dispersion of refractoriness and vulnerability to reentry.
Why the study?
Does pacing-induced discordant alternans and restitution properties increase vulnerability to reentrant arrhythmias in simulated cardiac tissue?
Population
Simulated 2D sheet of cardiac tissue using phase 1 of the Luo-Rudy cardiac action potential model
Comparison
Pacing from a single site at fast rates to… vs Absence of steep APD restitution and of CV…
Design
Preclinical
Authors
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Targeting restitution may reduce reentry risk; leaves open clinical translation from animal simulations.
Does pacing-induced discordant alternans and restitution properties increase vulnerability to reentrant arrhythmias in simulated cardiac tissue?
Discordant alternans arises dynamically from APD and CV restitution properties, increasing dispersion of refractoriness and vulnerability to reentrant arrhythmias, suggesting alteration of electrical restitution as a potential antiarrhythmic strategy.
Qu et al. (2000) studied Cardiac fibrillation and T-wave alternans. Pacing rate and restitution properties was evaluated on Discordant APD alternans and induction of reentry. Discordant alternans arises dynamically from action potential duration and conduction velocity restitution properties, markedly increasing dispersion of refractoriness and vulnerability to reentry.
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