January 25, 2008AJP Heart and Circulatory Physiology
Spatially discordant alternans in cardiomyocyte monolayers
Population
Monolayers of cultured neonatal rat ventricular myocytes
Comparison
Rapid pacing and exposure to BAY K 8644 vs Control conditions
Design
Preclinical
Authors
Discussion
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Implication
May inform arrhythmia mechanisms in simplified models; leaves open translation to intact hearts or clinical risk.
Structured PICO
P
Population
Monolayers of cultured neonatal rat ventricular myocytes (n=37 under control conditions, n=28 after BAY K 8644)
I
Intervention
Rapid pacing and exposure to BAY K 8644
C
Comparator
Control conditions (rapid pacing before BAY K 8644 exposure)
O
Outcome
Action potential duration (APD) alternans and intracellular Ca (Cai) transient alternans, including spatial discordancesurrogate
Spatially discordant alternans severe enough to initiate reentry can be readily induced by pacing in two-dimensional cardiac tissue, behaving according to predictions for a dynamically generated mechanism.
Cite This Study
Diego et al. (2008) studied this question.