Key result
A discrete-time kinematic model successfully predicted phase reversals and spatial discordance in interbeat interval and action potential duration during alternate pacing in cardiac myocyte models.
Population
One-dimensional cardiac myocyte model (discrete-time kinematic and cardiomyocyte ionic models)
Design
Preclinical
Authors
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May refine alternans modeling; leaves open translation to tissue or clinical instability.
A novel discrete-time kinematic model successfully predicts spatial discordance and phase reversals during alternate pacing, providing a new approach to predict instability in cardiac tissue.
Seth H. Weinberg (2015) studied Cardiac alternans and arrhythmias. Alternate pacing was evaluated on Phase reversals and spatial discordance in the interbeat interval (IBI) and action potential duration (APD). A discrete-time kinematic model successfully predicted phase reversals and spatial discordance in interbeat interval and action potential duration during alternate pacing in cardiac myocyte models.
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