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April 24, 2001Circulation

Electrical Storm Presages Nonsudden Death

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Why the study?

Does electrical storm increase the risk of subsequent death in patients with an implantable cardioverter defibrillator?

Population

457 patients who received an implantable cardioverter defibrillator in the Antiarrhythmics Versus…

Comparison

Electrical storm vs VT/VF unrelated to electrical storm and…

Design

Cohort

Follow-up

31 +/- 13 months

Key result

Electrical storm in ICD recipients was an independent risk factor for subsequent death (RR 2.4; 95% CI 1.3 to 4.2; P=0.003), with the greatest risk occurring in the first 3 months.

Authors

DEDerek V. ExnerSPSergio L. PinskiDWD. George Wyse

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Overview

Electrical storm signals high short-term mortality risk in ICD recipients; hypothesis-generating for targeted interventions.

Study Design

Type

Cohort (n=457)

Structured PICO

Does electrical storm increase the risk of subsequent death in patients with an implantable cardioverter defibrillator?

P
Population
457 patients who received an implantable cardioverter defibrillator (ICD) in the Antiarrhythmics Versus Implantable Defibrillators (AVID) trial
I
Intervention
Electrical storm (defined as ≥ 3 separate episodes of VT/VF within 24 hours) (n=90)
C
Comparator
VT/VF unrelated to electrical storm (n=184) and remaining patients without VT/VF (n=183)
O
Outcome
Subsequent death (survival evaluated using time-dependent Cox modeling)hard clinical

Main Result

Effect estimate: RR 2.4 (95% CI 1.3 to 4.2)

p-value: p=0.003

Electrical storm is an important, independent marker for subsequent death among ICD recipients, particularly in the first 3 months after its occurrence.

Cite This Study

Exner et al. (2001) conducted a cohort in ICD recipients (n=457). Electrical storm vs. VT/VF unrelated to electrical storm or no VT/VF was evaluated on Subsequent death (RR 2.4, 95% CI 1.3 to 4.2, p=0.003). Electrical storm in ICD recipients was an independent risk factor for subsequent death (RR 2.4; 95% CI 1.3 to 4.2; P=0.003), with the greatest risk occurring in the first 3 months.

synapsesocial.com/papers/6a0f427f5725bbd5cc5f9b59https://doi.org/10.1161/01.cir.103.16.2066
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