Key result
Genetic polymorphisms in VKORC1 and CYP2C9, along with age and body weight, independently accounted for 57% of the interindividual and inter-population variability in warfarin maintenance doses.
Why the study?
Do VKORC1 and CYP2C9 polymorphisms explain intra- and inter-population differences in warfarin maintenance dose requirements among Japanese, Caucasians, and African-Americans?
Population
157 Caucasians, 172 Japanese, and 36 African-Americans stably anticoagulated patients, along with 66 healthy…
Comparison
Genotyping for seven CYP2C9 variants and seven… vs Comparisons across different racial/ethnic…
Design
Cross-sectional
Authors
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May inform personalized warfarin dosing across groups; leaves open prospective validation before practice change.
Observational (n=365)
Yes
Do VKORC1 and CYP2C9 polymorphisms explain intra- and inter-population differences in warfarin maintenance dose requirements among Japanese, Caucasians, and African-Americans?
Absolute Event Rate: 5.5% vs 3.5%
p-value: p=<0.01
VKORC1 and CYP2C9 polymorphisms significantly contribute to both intra- and inter-population differences in warfarin maintenance dose requirements among Japanese, Caucasian, and African-American populations.
Takahashi et al. (2006) conducted an observational in Patients requiring stable anticoagulation therapy (n=365). Warfarin vs. Inter-population and inter-genotype comparison (Caucasians vs Japanese vs African-Americans; VKORC1 and CYP2C9 variants) was evaluated on Median daily warfarin maintenance dose (Caucasians vs Japanese) (p=<0.01). Genetic polymorphisms in VKORC1 and CYP2C9, along with age and body weight, independently accounted for 57% of the interindividual and inter-population variability in warfarin maintenance doses.
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