Why the study?
Do variations in VKORC1, CYP2C9, and CYP2C19 genes explain the interpatient variability in warfarin maintenance dose in Japanese patients?
Do variations in VKORC1, CYP2C9, and CYP2C19 genes explain the interpatient variability in warfarin maintenance dose in Japanese patients?
VKORC1 and CYP2C9 gene variations are major contributors to the interpatient and ethnic variability in warfarin maintenance dose requirements in Japanese patients.
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May inform initial dosing in Japanese patients; leaves open CYP roles and prospective outcome trials.
Obayashi et al. (2006) studied this question.
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