Why the study?
Does the CYP4F2 V433M polymorphism affect the required maintenance dose and serum concentration of warfarin in Japanese patients?
Does the CYP4F2 V433M polymorphism affect the required maintenance dose and serum concentration of warfarin in Japanese patients?
The CYP4F2 V433M polymorphism has a small but significant effect on increasing the required warfarin maintenance dose in Japanese patients, though its impact is less than that of CYP2C9 and VKORC1 polymorphisms.
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CYP4F2 CT genotype was associated with higher warfarin maintenance dose in Japanese patients; leaves open utility in dosing algorithms beyond CYP2C9/VKORC1.
Nakamura et al. (2011) studied this question.
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