What is the clinical evidence from this study?

Study design: Other. Population: Intra-atrial reentry (n=10). Intervention: Premature stimulus (S2) and acetylcholine perfusion. Primary outcome: Mean life span of reentry (rotations) (p=<0.001).

What question did this study set out to answer?

This study aims to explore how pectinate muscle bundles contribute to the development and persistence of intra-atrial reentry.

August 24, 1998Circulation ResearchOpen Access

Role of Pectinate Muscle Bundles in the Generation and Maintenance of Intra-atrial Reentry

Q: What are the key findings of this study?

In isolated canine right atrial tissues, stationary reentry anchored to large pectinate muscle ridges had a significantly longer mean life span than nonstationary reentry (102 vs 3.8 rotations, P<0.001).

Q: What question did this study set out to answer?

This study aims to explore how pectinate muscle bundles contribute to the development and persistence of intra-atrial reentry.

View Full Paper

Ask AI

Bookmark

Key result

In isolated canine right atrial tissues, stationary reentry anchored to large pectinate muscle ridges had a significantly longer mean life span than nonstationary reentry (102 vs 3.8 rotations, P<0.001).

Population

10 isolated canine right atrial tissues and computer simulation models

Design

Preclinical

Authors

TWTsu-Juey WuNational Yang Ming Chiao Tung University MYMasaaki YashimaNippon Medical School FXFagen XieKaiser Permanente

Discussion

Member takes

Implication

Pectinate ridge anchoring may stabilize atrial reentry; hypothesis-generating for targeted ablation strategies in patients.

Key Points

This study aims to explore how pectinate muscle bundles contribute to the development and persistence of intra-atrial reentry.
10 isolated canine right atrial tissues were perfused with acetylcholine.
Reentry was induced by premature stimuli and mapped with 477 bipolar electrodes.
Computer simulations assessed the effect of myocardial thickness on reentry.
28 episodes of stationary reentry initiated by conduction block along pectinate muscle ridges (P<0.001).
Reentrant activities transformed from fibrillation to flutter when anchored to PM ridges.
Nonstationary reentry occurred in areas without large PMs and had a significantly shorter lifespan.

Structured PICO

Population

10 isolated canine right atrial tissues and computer simulation models

Intervention

Perfusion with Tyrode's solution containing 1 to 2.5 micromol/L acetylcholine (ACh) and premature stimulus (S2) to induce reentry

Outcome

Role of pectinate muscle bundles in the formation and maintenance of intra-atrial reentry (wave break, anchoring, life span)surrogate

Main Result

Absolute Event Rate: 102% vs 3.8%

p-value: p=<0.001

Pectinate muscle ridges act as anchoring sites for reentrant wave fronts, lengthening the life span of reentry and determining the transition between fibrillation-like and flutter-like activity.

Cite This Study

Wu et al. (1998) studied Intra-atrial reentry (n=10). Premature stimulus (S2) and acetylcholine perfusion was evaluated on Mean life span of reentry (rotations) (p=<0.001). In isolated canine right atrial tissues, stationary reentry anchored to large pectinate muscle ridges had a significantly longer mean life span than nonstationary reentry (102 vs 3.8 rotations, P<0.001).

synapsesocial.com/papers/6a0f4fb1853d174eb2ed0f92 https://doi.org/10.1161/01.res.83.4.448

Topics

Atrial fibrillation Persistent AF management

View Full Paper

Ask AI

Bookmark

Role of Pectinate Muscle Bundles in the Generation and Maintenance of Intra-atrial Reentry

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Topics

Role of Pectinate Muscle Bundles in the Generation and Maintenance of Intra-atrial Reentry

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Also Consider

Topics

Also Consider