A morphologically realistic atrial computer model demonstrated that specific anatomic structures, such as the coronary sinus muscular sheath, play critical roles in stabilizing reentrant circuits.
How do specific anatomic structures affect reentry induction and maintenance in a morphologically realistic atrial model?
A morphologically realistic computational model of the atria demonstrates that specific anatomic structures, such as the coronary sinus muscular sheath and venae cavae openings, play critical roles in the induction and maintenance of reentrant circuits.
INTRODUCTION: Atrial fibrillation is the most common cardiac arrhythmia. In ablation procedures, identification of the reentrant pathways is vital. This has proven difficult because of the complex morphology of the atria. The purpose of this study was to ascertain the role of specific anatomic structures on reentry induction and maintenance. METHOD AND RESULTS: A computationally efficient, morphologically realistic, computer model of the atria was developed that incorporates its major structural features, including discrete electrical connections between the right and left atria, physiologic fiber orientation in three dimensions, muscle structures representing the crista terminalis (CT) and pectinate muscles, and openings for the veins and AV valves. Reentries were induced near the venous openings in the left and right atria, the mouth of the coronary sinus, and the free wall of the right atrium. The roles of certain muscular structures were ascertained by selectively removing the structures and observing how the propagation of activity was affected. CONCLUSION: (1) The muscular sheath of the coronary sinus acts as a pathway for a reentrant circuit and stabilizes any circuits that utilize the isthmus near the inferior vena cava. (2) Poor trans-CT coupling serves to stabilize flutter circuits. (3) Wall thickness is an important factor in the propagation of electrical activity, especially in the left atrium. (4) The openings of the inferior and superior venae cavae form natural anatomic anchors that make reentry easier to initiate by allowing for smaller ectopic beats to induce reentry.
Vigmond et al. (Sat,) conducted a other in Atrial fibrillation. Selective removal of muscular structures in a computer model was evaluated on Role of specific anatomic structures on reentry induction and maintenance. A morphologically realistic atrial computer model demonstrated that specific anatomic structures, such as the coronary sinus muscular sheath, play critical roles in stabilizing reentrant circuits.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: