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November 24, 2021Scientific ReportsOpen Access

Responses of different functional tests in candidates for bariatric surgery and the association with body composition, metabolic and lipid profile

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Key result

Fat mass and LDL explain 30% of peak VO2 variance in bariatric surgery candidates.

  • R2 0.30
  • P<0.05
  • n=44

Why the study?

Individuals with obesity can have metabolic disorders affecting exercise ability, prompting investigation into how body composition and metabolic and lipid profiles influence maximal and submaximal functional test performance.

Do different functional tests (ITMT, 6MWT, 2MST) elicit different metabolic and cardiovascular responses in obese candidates for bariatric surgery?

Population

Forty-four individuals with obesity, aged 18–50 years

Comparison

ITMT vs 6MWT vs 2MST

Authors

PRPaula Angélica RicciLALarissa Delgado AndréSJSoraia Pilon Jürgensen

Discussion

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Overview

Fat mass and LDL may influence VO2 in bariatric candidates; leaves open causal effects and intervention targets for prospective study.

Study Design

Type

Cross-Sectional (n=44)

Multicenter

No

Structured PICO

Do different functional tests (ITMT, 6MWT, 2MST) elicit different metabolic and cardiovascular responses in obese candidates for bariatric surgery?

P
Population
44 individuals with obesity (BMI ≥ 35 kg/m2 with comorbidities or BMI ≥ 40 kg/m2), aged 18–50 years, awaiting bariatric surgery. Mean age 36.3, 81.8% female, Brazil-based. Key exclusions: history of heart disease, uncontrolled hypertension, beta-blocker use, respiratory diseases, orthopedic/neurological impairments.
I
Intervention
Incremental treadmill test (ITMT), 6-minute walk test (6MWT), and 2-minute step test (2MST)
C
Comparator
Comparison between the three functional tests (ITMT vs 6MWT vs 2MST)
O
Outcome
Metabolic, ventilatory, cardiovascular, and perceived exertion demand (including VO2, HR, VE, RER, blood pressure, dyspnea, and leg fatigue)surrogate

Main Result

Effect estimate: R2 0.30

p-value: p=<0.05

In obese candidates for bariatric surgery, the 2-minute step test elicits higher metabolic and chronotropic demands than the 6-minute walk test, making it a viable submaximal alternative when maximal testing is not feasible.

Limitations

  • Findings cannot be extrapolated to individuals who have neurological, cardiac, or respiratory disorders
  • Did not evaluate endothelial function
  • Did not evaluate the infiltration of intramuscular fat through magnetic resonance imaging
  • Sample consisted mostly of women

Cite This Study

Ricci et al. (2021) conducted a cross-sectional in Obesity (candidates for bariatric surgery) (n=44). Incremental treadmill test (ITMT) vs. Six-minute walk test (6MWT) and two-minute step test (2MST) was evaluated on Variance in V̇O2 peak during ITMT explained by fat mass and LDL (R2 0.30, p=<0.05). Fat mass and low-density lipoprotein explained 30% of the variance in maximal oxygen uptake during the incremental treadmill test in candidates for bariatric surgery.

synapsesocial.com/papers/6a0f4ff834fbf15957ed1cfahttps://doi.org/10.1038/s41598-021-02072-x
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