Key result
Obesity and diabesity in rats alter ventricular muscle structure, potentially driving Ca2+ signaling defects.
Why the study?
Cardiovascular complications are a leading cause of morbidity and mortality in diabetic patients, prompting investigation into the effects of obesity and diabesity on ventricular myocyte function and structure.
Does obesity and diabesity alter ventricular muscle structure and function in Zucker rats?
Does obesity and diabesity alter ventricular muscle structure and function in Zucker rats?
Obesity and diabesity alter ventricular muscle proteins and structure, which may partly underlie defects in Ca2+ signaling in Zucker rat hearts.
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Should not change clinical practice in obesity or diabetes; leaves open human translation of these structural changes.
Sultan et al. (2022) studied Obesity and diabesity. Obesity and diabesity (ZF and ZDF rats) vs. Zucker lean (ZL) control rats was evaluated on Ventricular muscle structure and function (shortening, intracellular Ca2+, protein expression, structure). Obesity and diabesity in Zucker rats altered ventricular muscle proteins and structure, including reduced sarcomere length and mitochondria count, which may underlie defects in Ca2+ signaling.
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