January 8, 2011Experimental PhysiologyOpen Access

Changing pattern of gene expression is associated with ventricular myocyte dysfunction and altered mechanisms of Ca2+signalling in young type 2 Zucker diabetic fatty rat heart

Q: What is the clinical evidence from this study?

Study design: Other. Population: Type 2 diabetes and obesity. Intervention: Zucker diabetic fatty (ZDF) genotype/phenotype vs. Age-matched control rats. Primary outcome: L-type Ca(2+) current density at 0 mV.

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Key result

Young type 2 Zucker diabetic fatty rats exhibited prolonged ventricular myocyte time-to-peak shortening (163 vs 136 ms) and reduced L-type Ca2+ current density (1.19 vs 2.42 pA/pF) compared to controls.

Population

Young (9- to 13-week-old) type 2 Zucker diabetic fatty (ZDF) rats

Comparison

Type 2 diabetes and obesity disease model vs Age-matched control rats

Design

Preclinical

Authors

FHFrank Christopher HowarthUnited Arab Emirates University MQM. A. QureshiArmed Forces Hospital ZHZahra Al HassanUniversity of Baghdad

Discussion

Member takes

Implication

Preserved early myocyte shortening in diabetic rats does not guide management; leaves open progression to human contractile dysfunction.

Structured PICO

Population

Young (9- to 13-week-old) type 2 Zucker diabetic fatty rats compared with age-matched control rats to investigate early changes in cardiac muscle regulatory genes and myocyte function.

Exposure

Type 2 diabetes and obesity disease model (ZDF rats)

Comparator

Age-matched control rats

Outcome

Changes in the pattern of genes encoding cardiac muscle regulatory proteins, ventricular myocyte contraction, and Ca(2+) transportsurrogate

Main Result

Absolute Event Rate: 1.19% vs 2.42%

Young type 2 diabetic rats exhibit early alterations in ventricular myocyte contraction and calcium signaling associated with changes in gene expression of cardiac muscle and calcium channel proteins.

Cite This Study

Howarth et al. (2011) studied Type 2 diabetes and obesity. Zucker diabetic fatty (ZDF) genotype/phenotype vs. Age-matched control rats was evaluated on L-type Ca(2+) current density at 0 mV. Young type 2 Zucker diabetic fatty rats exhibited prolonged ventricular myocyte time-to-peak shortening (163 vs 136 ms) and reduced L-type Ca2+ current density (1.19 vs 2.42 pA/pF) compared to controls.

synapsesocial.com/papers/6a5d73b8eea3ca268888058b https://doi.org/10.1113/expphysiol.2010.055574

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Changing pattern of gene expression is associated with ventricular myocyte dysfunction and altered mechanisms of Ca2+signalling in young type 2 Zucker diabetic fatty rat heart

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

Changing pattern of gene expression is associated with ventricular myocyte dysfunction and altered mechanisms of Ca2+signalling in young type 2 Zucker diabetic fatty rat heart

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider