Key result
Tissue Doppler imaging detected reduced myocardial velocities in mutation-positive subjects without left ventricular hypertrophy with 100% sensitivity and 93% specificity.
Why the study?
Does Tissue Doppler imaging detect myocardial abnormalities in patients with familial hypertrophic cardiomyopathy mutations before the development of left ventricular hypertrophy?
Case-Control (n=73)
Does Tissue Doppler imaging detect myocardial abnormalities in patients with familial hypertrophic cardiomyopathy mutations before the development of left ventricular hypertrophy?
p-value: p=<0.001
Tissue Doppler imaging can accurately identify myocardial abnormalities in patients with hypertrophic cardiomyopathy mutations even before the development of left ventricular hypertrophy.
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Supports TDI for preclinical detection in HCM mutation carriers; leaves open whether screening alters outcomes.
Nagueh et al. (2001) conducted a case-control in Familial hypertrophic cardiomyopathy (n=73). Tissue Doppler imaging vs. Healthy controls was evaluated on Systolic and early diastolic tissue Doppler velocities (p=<0.001). Tissue Doppler imaging detected reduced myocardial velocities in mutation-positive subjects without left ventricular hypertrophy with 100% sensitivity and 93% specificity.
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