Key result
Review details the classification, hierarchy, and interpretation of clinical, surrogate, and composite cardiology endpoints.
Why the study?
Randomized controlled trials require determining endpoints in advance to answer clinical questions, which directly affects study design and sample size.
Design
Review
Authors
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May refine endpoint selection in cardiology trials; leaves open empirical validation of hierarchies in contemporary designs.
This review provides a comprehensive overview of endpoint selection, classification, and interpretation in cardiology clinical trials.
Navasardyan et al. (2022) conducted a review in Cardiology. This review provides a classification and hierarchy of endpoints in cardiology studies, detailing the use and interpretation of clinical outcomes, surrogate indicators, and composite endpoints.
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