Key result
Myomectomy in one of two identical twin boys with hypertrophic cardiomyopathy resulted in moderate incapacitation at 7-year follow-up, whereas the unoperated twin led a relatively normal life.
Case Report (n=2)
Identical twins with hypertrophic cardiomyopathy can exhibit markedly divergent phenotypic expression and clinical courses.
Case does not justify myomectomy in pediatric HCM; leaves open determinants of divergent courses in identical twins.
Hypertrophic cardiomyopathy was diagnosed in identical twin boys in early childhood. One underwent myomectomy at the age of 12 years because of progressive severe exertional dyspnoea accompanied by considerable obstruction of the left ventricular outflow tract shown on both echocardiography and cardiac catheterisation. Seven years later, at the age of 19, he remains incapacitated to a moderate degree. By contrast, the other twin has led a relatively normal life to date and no left ventricular outflow obstruction has been shown.
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Reid et al. (1989) conducted a case report in Hypertrophic cardiomyopathy (n=2). Myomectomy vs. No surgery was evaluated on Clinical status and left ventricular outflow obstruction. Myomectomy in one of two identical twin boys with hypertrophic cardiomyopathy resulted in moderate incapacitation at 7-year follow-up, whereas the unoperated twin led a relatively normal life.
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