March 15, 1996Circulation
Plasma Angiotensin II, Predisposition to Hypertension, and Left Ventricular Size in Healthy Young Adults
Key result
Plasma angiotensin II levels correlated significantly with left ventricular mass (r=0.39, P<0.0001), independent of systolic blood pressure and body size in healthy young adults.
Why the study?
What are the correlates of left ventricular mass in healthy young adults predisposed to hypertension?
Population
84 healthy young adults aged 16 to 24 years from the general population, selected according to…
Design
Cross-sectional
Authors
Discussion
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Implication
Plasma angiotensin II may contribute to early left ventricular remodeling in young adults; cross-sectional data leave open causal and prognostic implications.
Study Design
Type
Cross-Sectional (n=84)
Structured PICO
What are the correlates of left ventricular mass in healthy young adults predisposed to hypertension?
P
Population
84 healthy young adults aged 16 to 24 years from the general population, selected according to predisposition to hypertension (high or low personal blood pressures and high or low parental blood pressures).
O
Outcome
Correlates of left ventricular mass (LVM) measured by echocardiographysurrogate
Main Result
Effect estimate: r = 0.39
p-value: p=<0.0001
Plasma angiotensin II correlates with left ventricular mass independently of blood pressure and body size, suggesting a direct effect on myocardial size.
Cite This Study
Harrap et al. (1996) conducted a cross-sectional in Healthy young adults (n=84). Plasma angiotensin II was evaluated on Correlates of left ventricular mass (LVM) (r = 0.39, p=<0.0001). Plasma angiotensin II levels correlated significantly with left ventricular mass (r=0.39, P<0.0001), independent of systolic blood pressure and body size in healthy young adults.