Standardization of M-mode echocardiographic left ventricular anatomic measurements
Why the study?
The study was conducted to improve the standardization of echocardiographic left ventricular anatomic measurements by relating left ventricular dimensions and mass to body size indexes, sex, age, and blood pressure.
Population
92 hospital-based subjects and 133 subjects from a population sample
Comparison
Left ventricular measurements compared across body size indexes, sex, age, and blood pressure
Design
Cross-sectional study
Authors
Discussion
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Member takes
Overview
Sex-specific norms may improve echo LV standardization; leaves open optimal body size indexing for age and BP in practice.
Key Points
- Determine the relationships between echocardiographic left ventricular dimensions, mass, body size metrics, sex, age, and blood pressure to establish standardized anatomical reference values.
- Evaluated two independent non-diseased cohorts totaling 225 participants: a hospital-based cohort of 92 subjects (64 women, 28 men) and a community cohort of 133 subjects (55 women, 78 men) aged 18 to 72 years.
- Measured left ventricular dimensions, wall thicknesses, and mass via M-mode echocardiography, indexing values against body surface area and 24-hour urine creatinine-estimated lean body mass.
- Left ventricular mass correlated most strongly with body surface area (r = 0.37, p < 0.01 to r = 0.57, p < 0.001), but significant sex differences persisted in left ventricular mass index (89 ± 21 g/m² in men vs. 69 ± 19 g/m² in women, p < 0.0001; 97th percentiles 132–136 g/m² vs. 109–112 g/m²).
- Lean body mass differed significantly by sex (58 ± 15 kg in men vs. 40 ± 13 kg in women, p < 0.001), and indexing left ventricular mass to lean body mass completely eliminated sex differences (3.4 ± 1.3 g/kg in men vs. 3.5 ± 1.5 g/kg in women).
- Left ventricular mass indexed to lean body mass correlated weakly with systolic blood pressure (r = 0.25, p < 0.05) and diastolic blood pressure (r = 0.28, p < 0.01), but showed no correlation with age.
Structured PICO
P
Population
225 normal subjects, comprising 92 hospital-based subjects (64 women, 28 men) and 133 subjects from a population sample (55 women, 78 men), aged 18 to 72 years.
I
Intervention
M-mode echocardiographic left ventricular anatomic measurements and indexation by body surface area and lean body mass.
O
Outcome
Left ventricular dimensions and mass in relation to body size indexes, sex, age, and blood pressure.surrogate
Sex differences in echocardiographic left ventricular mass index are eliminated when indexed by lean body mass rather than body surface area.
Cite This Study
Devereux et al. (1984) studied this question.