Key result
Heart transplant recipients show reduced LV longitudinal function vs controls, partially compensated by augmented lateral function.
Why the study?
It was unknown whether left ventricular longitudinal pumping is altered, associated with exercise capacity, or explained by right bundle branch block in heart-transplanted patients.
Is left ventricular longitudinal function altered in heart-transplanted patients compared to healthy controls, and is it associated with exercise capacity?
Observational (n=68)
No
Is left ventricular longitudinal function altered in heart-transplanted patients compared to healthy controls, and is it associated with exercise capacity?
Heart-transplanted patients exhibit reduced left ventricular longitudinal function that is partially compensated by increased radial function, but this altered pumping mechanic does not correlate with exercise capacity.
Altered LV mechanics post-transplant do not correlate with exercise capacity; hypothesis-generating for longitudinal outcome studies.
Background: In healthy hearts, left ventricular atrioventricular plane displacement (LVAVPD) measured by cardiac magnetic resonance (CMR) contributes to ∼60% of stroke volume. LVAVPD has been shown to correlate with maximal cardiac output and exercise capacity and is an independent predictor of outcomes in patients with heart failure. We aimed to assess if longitudinal pumping is altered, if LVAVPD is associated with exercise capacity, and if any difference in longitudinal pumping could be explained by the presence of a right bundle branch block (RBBB) in heart-transplanted patients. Method: This single-center study included 34 heart-transplanted patients who had undergone CMR and a cardiopulmonary exercise test as part of a clinical post-transplant surveillance program. Data was compared to 34 healthy sex- and age-matched controls. Conclusion: Heart-transplanted patients have decreased left ventricular longitudinal function compared to healthy controls, in part compensated by an augmented lateral function. Longitudinal function is not associated with cardiac output at rest or exercise capacity in this patient group. Whether the altered pumping mechanics seen are associated with outcome remains to be investigated.
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Gjesdal et al. (2025) conducted an observational in Heart transplantation (n=68). Heart transplantation vs. Healthy sex- and age-matched controls was evaluated on Left ventricular longitudinal function and association with exercise capacity. Heart-transplanted patients have decreased left ventricular longitudinal function compared to healthy controls, which is partially compensated by augmented lateral function.
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