Regional contribution to ventricular stroke volume is affected on the left side, but not on the right in patients with pulmonary hypertension
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Key result
Patients with pulmonary hypertension had a significantly lower longitudinal contribution to left ventricular stroke volume (51% vs 59%) compared to healthy controls, which was compensated by increased lateral contribution.
Population
17 adult patients evaluated for precapillary pulmonary hypertension with right heart catheterization and…
Design
Case-control
Authors
Discussion
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Implication
Altered LV mechanics in PH should not yet change practice; hypothesis-generating for longitudinal assessment in monitoring.
Study Design
Type
Cross-Sectional (n=50)
Multicenter
No
Structured PICO
P
Population
17 adult patients with precapillary pulmonary hypertension and 33 healthy controls underwent cardiac magnetic resonance imaging to quantify regional contributions to ventricular stroke volume.
C
Comparator
33 healthy adult volunteers (13 females)
O
Outcome
Longitudinal, septal, and lateral contributions to stroke volume in both ventricles quantified using cardiac magnetic resonancesurrogate
Main Result
Absolute Event Rate: 51% vs 59%
p-value: p=0.008
In patients with pulmonary hypertension, left ventricular regional pumping mechanics are altered with decreased longitudinal and increased lateral contributions to stroke volume, despite preserved global LV function.
Limitations
- Heterogeneous genesis of pulmonary hypertension in the study population.
- Significant age difference between the patient and control groups.
- Small sample size and retrospective inclusion.
- small sample size
- retrospective inclusion
Cite This Study
Ostenfeld et al. (2016) conducted a cross-sectional in Pulmonary hypertension (n=50). Pulmonary hypertension vs. Healthy controls was evaluated on Longitudinal contribution to left ventricular stroke volume (LVSVlong%) (p=0.008). Patients with pulmonary hypertension had a significantly lower longitudinal contribution to left ventricular stroke volume (51% vs 59%) compared to healthy controls, which was compensated by increased lateral contribution.
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