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January 18, 2014AJP Heart and Circulatory Physiology

The relationship between longitudinal, lateral, and septal contribution to stroke volume in patients with pulmonary regurgitation and healthy volunteers

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Key result

Pulmonary regurgitation was associated with a decreased longitudinal contribution to right ventricular stroke volume compared to healthy controls (47% vs 79%, P<0.001).

Population

84 subjects: 30 patients with pulmonary regurgitation due to surgically corrected tetralogy of Fallot and 54…

Design

Case-control

Authors

SSSigurdur S. StephensenNational University Hospital of IcelandKSKatarina Steding‐EhrenborgLund UniversityPMPeter MunkhammarLund University

Discussion

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Implication

May limit TAPSE validity for RV function in pulmonary regurgitation; hypothesis-generating for alternative metrics post-tetralogy repair.

Study Design

Type

Observational (n=84)

Structured PICO

P
Population
84 participants, comprising 30 patients aged 9-59 years with pulmonary regurgitation due to surgically corrected tetralogy of Fallot and 54 healthy controls aged 10-66 years.
C
Comparator
Healthy controls
O
Outcome
Longitudinal, lateral, and septal contribution to right and left ventricular stroke volume (RVSV and LVSV)surrogate

Main Result

Absolute Event Rate: 47% vs 79%

p-value: p=<0.001

In patients with pulmonary regurgitation after tetralogy of Fallot repair, right ventricular pumping physiology shifts from longitudinal to lateral and septal contributions, suggesting tricuspid annular excursion is a less valid marker of RV function in this population.

Cite This Study

Stephensen et al. (2014) conducted an observational in Pulmonary regurgitation (n=84). Pulmonary regurgitation vs. Healthy controls was evaluated on Longitudinal contribution to right ventricular stroke volume (RVSV) (p=<0.001). Pulmonary regurgitation was associated with a decreased longitudinal contribution to right ventricular stroke volume compared to healthy controls (47% vs 79%, P<0.001).

synapsesocial.com/papers/6a735c7e4e82b1a46ac67ddchttps://doi.org/10.1152/ajpheart.00483.2013
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Left atrial conduit volume is generated by deviation from the constant-volume state of the left heart: a combined MRI-echocardiographic study2004 · 113 citations
  2. 2MRI-determined left ventricular “crescent effect”: a consequence of the slight deviation of contents of the pericardial sack from the constant-volume state2004 · 35 citations
  3. 3Atrial aspiration from pulmonary and caval veins is caused by ventricular contraction and secures 70% of the total stroke volume independent of resting heart rate and heart size2013 · 49 citations
  4. 4Restrictive right ventricular physiology after Tetralogy of Fallot repair is associated with fibrosis of the right ventricular outflow tract visualized on cardiac magnetic resonance imaging2013 · 56 citations
  5. 5Assessment and consequences of the constant-volume attribute of the four-chambered heart2003 · 72 citations