Key result
Right ventricular volume overload significantly depressed left ventricular ejection fraction (51% vs 60% in controls, P<0.001), whereas right ventricular pressure overload preserved it (56%, P=0.07).
Why the study?
Do right ventricular pressure overload and volume overload have different effects on left ventricular ejection fraction?
Population
30 subjects total: 10 patients with severe tricuspid regurgitation after tricuspid valve resection for…
Comparison
Right ventricular volume overload and right… vs Healthy control subjects
Design
Cross-sectional
Authors
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RV volume overload may impair LV function more than pressure overload; hypothesis-generating and requires prospective validation before guiding management.
Observational (n=30)
Do right ventricular pressure overload and volume overload have different effects on left ventricular ejection fraction?
Absolute Event Rate: 51% vs 60%
p-value: p=<.001
Right ventricular pressure overload preserves left ventricular ejection fraction through end-systolic leftward septal shift, whereas right ventricular volume overload depresses it due to end-diastolic leftward septal shift.
Louie et al. (1995) conducted an observational in Right ventricular volume overload and right ventricular pressure overload (n=30). Right ventricular volume overload (RVVO) vs. Healthy control subjects was evaluated on Left ventricular ejection fraction (p=<.001). Right ventricular volume overload significantly depressed left ventricular ejection fraction (51% vs 60% in controls, P<0.001), whereas right ventricular pressure overload preserved it (56%, P=0.07).
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