Key result
Patients with pulmonary hypertension had prolonged left ventricular isovolumic relaxation time compared to controls (80 vs 50 ms, p<0.001), suggesting right-left ventricular asynchrony.
Why the study?
Does pulmonary hypertension alter left ventricular filling characteristics and isovolumic relaxation compared to normal pulmonary artery pressure in patients with right ventricular enlargement?
Population
39 patients without intrinsic left ventricular disease, comprising 29 patients with pulmonary hypertension…
Design
Cross-sectional
Authors
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PH may impair LV filling via RV-LV interaction; hypothesis-generating and should not yet change practice.
Observational (n=39)
No
Does pulmonary hypertension alter left ventricular filling characteristics and isovolumic relaxation compared to normal pulmonary artery pressure in patients with right ventricular enlargement?
Absolute Event Rate: 80% vs 50%
p-value: p=<0.001
Severe pulmonary hypertension prolongs right ventricular tension decline, which persists after mitral valve opening and impairs left ventricular isovolumic relaxation and filling, demonstrating a mechanism of right-left ventricular interaction.
Stojnić et al. (1992) conducted an observational in Pulmonary hypertension (n=39). Pulmonary hypertension vs. Enlarged right ventricle with normal pulmonary artery pressure was evaluated on Isovolumic relaxation time (A2 to mitral valve opening) (p=<0.001). Patients with pulmonary hypertension had prolonged left ventricular isovolumic relaxation time compared to controls (80 vs 50 ms, p<0.001), suggesting right-left ventricular asynchrony.
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