Key result
Decreased left ventricular free wall systolic strain in pulmonary arterial hypertension was associated with increased mortality (adjusted HR 3.11 per 5% decrease; 95% CI 1.38-7.20).
Why the study?
Does left ventricular free wall systolic strain predict mortality in adults with newly diagnosed pulmonary arterial hypertension?
Population
71 adults with a new diagnosis of pulmonary arterial hypertension (PAH)
Design
Cohort
Follow-up
>2 years
Authors
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May enhance mortality risk stratification in new PAH; hypothesis-generating pending prospective validation.
Cohort (n=71)
Does left ventricular free wall systolic strain predict mortality in adults with newly diagnosed pulmonary arterial hypertension?
Effect estimate: Adjusted HR 3.11 (95% CI 1.38-7.20)
In patients with newly diagnosed PAH, reduced LV free wall systolic strain is associated with early mortality despite preserved LV ejection fraction, highlighting the prognostic importance of ventricular interdependence.
Hardegree et al. (2013) conducted a cohort in Pulmonary arterial hypertension (n=71). Left ventricular free wall systolic strain was evaluated on Mortality (Adjusted HR 3.11, 95% CI 1.38-7.20). Decreased left ventricular free wall systolic strain in pulmonary arterial hypertension was associated with increased mortality (adjusted HR 3.11 per 5% decrease; 95% CI 1.38-7.20).
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