Key result
PAWP weakly correlates only with LAVi in advanced pulmonary hypertension, limiting conventional echo accuracy.
Why the study?
Evaluating left ventricular filling pressure is important in managing pulmonary hypertension, but the accuracy of echocardiographic parameters in the presence of pulmonary vascular lesions had not been fully addressed.
Do conventional echocardiographic parameters accurately reflect left ventricular filling pressure in patients with advanced pulmonary vascular lesions?
Population
124 patients with noncardiac pulmonary hypertension and 113 patients with ischemic heart disease
Comparison
Noncardiac pulmonary hypertension subdivided by median pulmonary vascular resistance vs ischemic heart disease controls
Design
Retrospective study
Authors
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May limit reliability of echo estimates of LV filling pressure in advanced PH; hypothesis-generating for LA volume index validation.
Observational (n=237)
Do conventional echocardiographic parameters accurately reflect left ventricular filling pressure in patients with advanced pulmonary vascular lesions?
Conventional echocardiographic parameters may not accurately reflect left ventricular filling pressure in patients with advanced pulmonary vascular lesions due to the blunting effect of elevated pulmonary vascular resistance.
Chiba et al. (2020) conducted an observational in Pulmonary hypertension (n=237). Echocardiography vs. Right heart catheterization was evaluated on Correlation between pulmonary artery wedge pressure and echocardiographic parameters. In advanced pulmonary hypertension, pulmonary artery wedge pressure correlated only with left atrial volume index (R=0.27, P=0.032), limiting the accuracy of conventional echocardiographic parameters.
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