Key result
Right ventricular pressure overload was associated with greater regional diastolic motion heterogeneity compared to healthy controls (p<0.01), correlating with the RV/LV pressure ratio (r=0.77, p<0.05).
Why the study?
Does right ventricular pressure overload alter regional left ventricular diastolic motion compared to healthy controls?
Observational (n=15)
Does right ventricular pressure overload alter regional left ventricular diastolic motion compared to healthy controls?
Right ventricular pressure overload is associated with depressed septal regional diastolic fraction and increased heterogeneity in left ventricular regional diastolic motion, which correlates with the severity of the pressure overload.
May reflect ventricular interdependence in RV overload; leaves open whether heterogeneity affects outcomes or requires prospective study.
Global left ventricular (LV) diastolic function has been reported to be disturbed under conditions of right ventricular pressure overload (RVPO). However, from the standpoint of regional wall motion, only a little information related to the mechanism of LV diastolic dysfunction is available. Eight patients with RVPO and 7 healthy volunteers were investigated using tagged cine magnetic resonance imaging. Regional diastolic fraction (RDF) was determined in 4 segments (anterior, lateral, inferior, and septal) in the mid-ventricular short axis section and in 2 segments (septal and lateral) in the 4-chamber section. A heterogeneity index was obtained from the RDFs of the short axis section. In the RVPO group, in both short axis and 4-chamber sections, the RDF of the septal segment was depressed, and it showed an inverse correlation with the right-to-left ventricular systolic pressure (RV/LV) ratio (r = -0.74, p < 0.05) in the short axis section. In the 4-chamber section, the RDF was lower in the septal segment than in the lateral segment (p < 0.05). The heterogeneity index in the RVPO group was greater than that in the control group (p < 0.01). The index correlated positively with the RV/LV ratio (r = 0.77, p < 0.05). The altered regional diastolic motion results in increased heterogeneity in regional diastolic motion.
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Kurotobi et al. (1999) conducted an observational in Right ventricular pressure overload (n=15). Tagged cine magnetic resonance imaging vs. Healthy volunteers was evaluated on Regional diastolic fraction (RDF) and heterogeneity index (p=< 0.01). Right ventricular pressure overload was associated with greater regional diastolic motion heterogeneity compared to healthy controls (p<0.01), correlating with the RV/LV pressure ratio (r=0.77, p<0.05).
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