Key result
Myocardial energy expenditure over ~3146 kcal/systole is linked to higher one-year mortality in HFpEF.
Why the study?
To explore the correlation between myocardial energy expenditure characteristics and the degree of diastolic dysfunction in HFpEF and assess its clinical significance.
Does high myocardial energy expenditure predict 1-year mortality in patients with HFpEF?
Cohort (n=125)
No
Does high myocardial energy expenditure predict 1-year mortality in patients with HFpEF?
Elevated myocardial energy expenditure correlates with severe diastolic dysfunction and serves as a predictor of 1-year mortality in patients with HFpEF.
Answers are grounded in this paper and cite their sources.
Should not yet change HFpEF management; leaves open whether myocardial energy expenditure is a modifiable target.
Objective: To explore the correlation between characteristics of myocardial energy expenditure (MEE) and the degree of diastolic dysfunction in patients of heart failure with preserved ejection fraction (HFpEF) and its clinical significance. Methods: 125 consecutive patients diagnosed with HFpEF in the Department of Cardiology, Affiliated Zhongshan Hospital of Dalian University from January 2018 to October 2018 were enrolled. According to the degree of diastolic dysfunction, patients were divided into group A (8 ≤ E/e' ≤15) and group B (E/e'> 15), and MEE was calculated, patients finished 1-year clinical follow-up. Results: The level of MEE in group A was significantly lower than that in group B ( p < 0.05). During 1-year follow up, MEE over 3145.69 kcal/systole was associated with increased risk of death as compared to patients with MEE less 3145.69 kcal/systole, and in patients with MEE over 101.68 kcal/min than in patients with MEE less than 101.68 kcal/min. Conclusion: There is a significant correlation between MEE and diastolic dysfunction and MEE over 3145.69 kcal/systole as well as MEE over 101.68 kcal/min are linked with increased risk of 1-year mortality in HFpEF.
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Wang et al. (2022) conducted a cohort in Heart failure with preserved ejection fraction (HFpEF) (n=125). High Myocardial Energy Expenditure (MEE > 3145.69 kcal/systole) vs. Low Myocardial Energy Expenditure (MEE < 3145.69 kcal/systole) was evaluated on All-cause mortality at 1-year follow-up (p=0.019). Myocardial energy expenditure over 3145.69 kcal/systole was associated with a significantly increased risk of 1-year all-cause mortality in patients with HFpEF.
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