April 28, 2022ESC Heart FailureOpen Access

Low Mechano-Energetic Efficiency is Associated with Future Left Ventricular Systolic Dysfunction in Hypertensives

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Why the study?

In hypertensive patients with optimal blood pressure control, the study aimed to analyze predictors of left ventricular ejection fraction reduction, including indexed mechano-energetic efficiency.

Does low baseline mechano-energetic efficiency predict the development of left ventricular systolic dysfunction in hypertensive patients with normal baseline LVEF?

Population

5673 hypertensive patients with normal baseline LVEF and no prevalent CV disease

Comparison

Patients developing LVEF impairment vs patients with persistently normal LVEF

Design

Cohort study

Follow-up

Mean duration 5.6 ± 3.9 years

Authors

MMMaria Virginia Manzi CMCostantino Mancusi MLMaria Lembo

Discussion

Member takes

Overview

Low MEEi may flag risk for incident systolic dysfunction in controlled hypertension; hypothesis-generating and requires prospective validation.

Structured PICO

Does low baseline mechano-energetic efficiency predict the development of left ventricular systolic dysfunction in hypertensive patients with normal baseline LVEF?

Population

5,673 hypertensive patients with normal baseline LVEF (≥50%) and no prevalent cardiovascular disease, mean age 53.5, 58% male, from the Campania Salute Network (Italy).

Intervention

Lowest quartile of indexed mechano-energetic efficiency (MEEi ≤0.29 mL/s/g) at baseline

Comparator

Higher quartiles of indexed mechano-energetic efficiency (MEEi >0.29 mL/s/g) at baseline

Outcome

Development of left ventricular systolic dysfunction (defined as LVEF < 50% or a reduction of at least 10 percentage points compared with baseline)surrogate

In hypertensive patients with normal baseline ejection fraction, low mechano-energetic efficiency independently predicts the future development of left ventricular systolic dysfunction.

Cite This Study

Manzi et al. (2022) studied this question.

synapsesocial.com/papers/6a70bb43b5c1fe5ca9dfc00b https://doi.org/10.1002/ehf2.13908

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April 28, 2022ESC Heart FailureOpen Access

Low Mechano-Energetic Efficiency is Associated with Future Left Ventricular Systolic Dysfunction in Hypertensives

View Full Paper

Ask AI

Bookmark

Why the study?

In hypertensive patients with optimal blood pressure control, the study aimed to analyze predictors of left ventricular ejection fraction reduction, including indexed mechano-energetic efficiency.

Does low baseline mechano-energetic efficiency predict the development of left ventricular systolic dysfunction in hypertensive patients with normal baseline LVEF?

Population

5673 hypertensive patients with normal baseline LVEF and no prevalent CV disease

Comparison

Patients developing LVEF impairment vs patients with persistently normal LVEF

Design

Cohort study

Follow-up

Mean duration 5.6 ± 3.9 years

Authors

MMMaria Virginia Manzi CMCostantino Mancusi MLMaria Lembo

Discussion

Member takes

Overview

Low MEEi may flag risk for incident systolic dysfunction in controlled hypertension; hypothesis-generating and requires prospective validation.

Structured PICO

Does low baseline mechano-energetic efficiency predict the development of left ventricular systolic dysfunction in hypertensive patients with normal baseline LVEF?

Population

5,673 hypertensive patients with normal baseline LVEF (≥50%) and no prevalent cardiovascular disease, mean age 53.5, 58% male, from the Campania Salute Network (Italy).

Intervention

Lowest quartile of indexed mechano-energetic efficiency (MEEi ≤0.29 mL/s/g) at baseline

Comparator

Higher quartiles of indexed mechano-energetic efficiency (MEEi >0.29 mL/s/g) at baseline

Outcome

Development of left ventricular systolic dysfunction (defined as LVEF < 50% or a reduction of at least 10 percentage points compared with baseline)surrogate

In hypertensive patients with normal baseline ejection fraction, low mechano-energetic efficiency independently predicts the future development of left ventricular systolic dysfunction.

Cite This Study

Manzi et al. (2022) studied this question.

synapsesocial.com/papers/6a70bb43b5c1fe5ca9dfc00b https://doi.org/10.1002/ehf2.13908

View Full Paper

Ask AI

Bookmark