Key result
Higher NT-proBNP levels correlate with diastolic dysfunction severity, rising ~10-fold from Grade I to IV.
Why the study?
The study was conducted to evaluate the role of NT-proBNP in the diagnosis of diastolic heart failure and its correlation with echocardiography.
Does NT-proBNP level correlate with echocardiographic grading of diastolic dysfunction in patients with diastolic heart failure?
Observational (n=65)
No
Does NT-proBNP level correlate with echocardiographic grading of diastolic dysfunction in patients with diastolic heart failure?
Absolute Event Rate: 3570% vs 361.08%
p-value: p=<0.0001
NT-proBNP levels show a significant positive correlation with the severity of diastolic dysfunction as graded by echocardiography in patients with diastolic heart failure.
NT-proBNP may reflect diastolic dysfunction severity; observational data leaves open prospective validation before clinical adoption.
Background: The primary aim of the current investigation was to evaluate the role of NT-proBNP in the diagnosis of diastolic heart failure and its correlation with echocardiography.Methods: Hospital based observational and analytical study undertaken on a total of 65 patients of diastolic heart failure fulfilling clinical inclusion criteria. The enrolled patients had a mean age of 54.5 years with a female preponderance (33 females vs. 32 males). Patients underwent clinical evaluation and echocardiography examination. NT-proBNP estimation was done using autoanalyzer working on principle of electrochemiluminisense. Patients were divided into various grades of diastolic dysfunction on the basis of echocardiography. Statistical analysis was done to find the significance of levels of NT-proBNP and its correlation with the grading of diastolic heart failure.Results: There was a statistically significant higher level of serum NT-proBNP in patients with diastolic heart failure and the increasing levels were directly proportional to severity of diastolic dysfunction. The mean level of NT-proBNP increased from 361.08 pg/ml to 3570 pg/ml in increasing severity of diastolic dysfunction.Conclusions: Results suggested positive correlation of rising NT-proBNP levels with increasing severity of diastolic dysfunction.
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Toppo et al. (2021) conducted an observational in Diastolic heart failure (n=65). NT-proBNP measurement vs. Echocardiography grades of diastolic dysfunction was evaluated on Correlation of NT-proBNP levels with severity of diastolic dysfunction (p=<0.0001). Serum NT-proBNP levels showed a significant positive correlation with the severity of diastolic dysfunction, increasing from a mean of 361.08 pg/ml in Grade I to 3570 pg/ml in Grade IV (p<0.0001).
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