Key result
During partial sodium channel blockade with flecainide, right ventricular conduction velocity decreased by 35.3% compared to 29.2% in the left ventricle, indicating increased RV conduction dependence.
Population
Guinea pig right and left ventricles
Comparison
Flecainide (0.5 microM) and BaCl2 (10 microM) vs Control conditions
Design
Preclinical
Authors
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Indicates greater RV conduction sensitivity to flecainide in animals; hypothesis-generating for clinical RV arrhythmogenesis with sodium channel blockade.
Absolute Event Rate: 35.3% vs 29.2%
The right ventricle has an increased conduction dependence on sodium channel availability due to lower Na(v)1.5 expression compared to the left ventricle, providing a mechanism for increased RV conduction sensitivity to flecainide.
Veeraraghavan et al. (2007) studied Brugada syndrome and heart failure (experimental model). Flecainide challenge vs. Left ventricle vs Right ventricle was evaluated on Decrease in conduction velocity (theta) during flecainide challenge. During partial sodium channel blockade with flecainide, right ventricular conduction velocity decreased by 35.3% compared to 29.2% in the left ventricle, indicating increased RV conduction dependence.
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