In a Scn5a +/- mouse model, arrhythmogenesis appears to be driven by right ventricular effective refractory period gradients and conduction slowing rather than transmural repolarization gradients.
No takes yet. Share an insight, caveat, or question.
RV VERP gradients may promote arrhythmogenesis in Scn5a+/- models; leaves open translation to human Brugada syndrome.
Martin et al. (2011) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: